IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva / IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos.

ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials.

Development and clinical application of contrast enhanced ultrasound Liver Imaging Reporting and Data System / 临床肝胆病杂志

Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence in China and the whole world, and early diagnosis and treatment are the key to improving the prognosis of patients. To facilitate the communication and cooperation between doctors of different centers and specialties, American College of Radiology issued the first edition of contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) in 2016 to standardize the technical terms, techniques, interpretation, reporting, and data collection for liver imaging and perform HCC risk stratification for different focal liver lesions. This article reviews the development and clinical application of CEUS LI-RADS and believes that the application of CEUS LI-RADS has a great potential value in the clinical management of focal liver lesions in the population at a high risk of HCC, and the applicable population and indications for CEUS LI-RADS will continue to expand in the near future, so as to provide better service to clinical practice.

Construction and operation of hospital radiation protection management information system / 中华医院管理杂志

The construction and operation of the hospital-wide radiation protection management information system is of great significance for improving the efficiency and quality of radiation protection management. A hospital has built a hospital-wide radiation protection management system, which consisted of four modules: radiation staff management module, protection items management module, site and equipment management module, and self-inspection module. The system adopted B/S mode, carried the lightweight J2EE framework-SpringBoot framework, and used mybatis, which was flexible and practical, as the persistence layer of the system, to store the data completely in the SQLServer database.Java language was used as the system development language, and the front and back-end separation architecture was used. Each of the four modules implemented the management responsibility departments and responsible personnel to carry out the all-round management of radiation protection, and realized the integrated, information-based and standardized management of radiation protection management in the hospital.

Design and Implementation of Software Platform for AI-ECG Algorithm Research / 中国医疗器械杂志

A software platform for AI-ECG algorithm research is designed and implemented to better serve the research of ECG artificial intelligence classification algorithm and to solve the problem of subjects data information management. Matlab R2019b and MySQL Sever 8.0 are used to design the software platform. The software platform is divided into three modules including data management module, data receiving module and data processing module. The software platform can be used to query and set the subjects information. It has realized the functions of data receiving, signal processing and the display, analysis and storage of ECG data. The software platform is easy to operate and meets the basic needs of scientific research. It is of great significance to the research of AI-ECG algorithm.

Usability in the admission monitoring system of an emergency room / Usabilidade de um sistema de monitoramento das internações em pronto-socorro

ABSTRACT OBJECTIVE To develop and evaluate the usability of the admission monitoring system in an emergency room. METHODS This applied research intends to develop a software product and evaluate its usability. The development followed four stages: systematic review, structuring of the system framework, construction of system forms, and evaluation of the information generated. In the evaluation, the experts simulated the use of the system by inserting data from a fictitious medical record. We measured usability using the System Usability Scale (SUS). Scores and scores were calculated individually and globally. We propose these evaluation standards: worst case scenario, poor, average, good, excellent, and best-case scenario. RESULTS The Sistema de Informação e Monitoramento das Internações em Pronto-Socorro (SIMIPS - Information and Monitoring System for Emergency Room Admissions) monitors the epidemiological profile of admissions to the emergency room, time management, clinical deterioration, incidence of adverse events, and human resource management. The usability of SIMIPS, evaluated by 17 experts, reached the SUS Score 86.5 (best case scenario), and some suggestions for modifications were accepted. CONCLUSIONS We consider SIMIPS an easy-to-use tool, with real importance in the management of emergencies in view of overcrowding and congestion problems faced in Brazil.

RESUMO OBJETIVO Desenvolver e avaliar a usabilidade de um sistema de monitoramento das internações em pronto-socorro. MÉTODOS Trata-se de uma pesquisa aplicada, com desenvolvimento de um produto de software e avaliação de sua usabilidade por enfermeiros especialistas. O desenvolvimento seguiu quatro etapas: revisão sistemática, estruturação do arcabouço do sistema, construção dos formulários do sistema e avaliação das informações geradas. Na avaliação, os especialistas simularam a utilização do sistema com a inserção de dados de um prontuário fictício, e a usabilidade foi medida pelo System Usability Scale (SUS). A pontuação e os escores foram calculados de forma individual e global. O sistema foi avaliado nos padrões: pior imaginável, pobre, mediano, bom, excelente e melhor imaginável. RESULTADOS O Sistema de Informação e Monitoramento das Internações em Pronto-Socorro (SIMIPS) realiza o monitoramento do perfil epidemiológico das internações no pronto-socorro, gestão de tempo, deterioração clínica, incidência de eventos adversos e gestão de recursos humanos. A usabilidade do SIMIPS, avaliada por 17 especialistas, atingiu o Score SUS 86,5 (melhor imaginável), e algumas sugestões de modificações foram acatadas. CONCLUSÕES O SIMIPS foi avaliado como uma ferramenta de fácil utilização, com real importância na gestão das urgências frente aos problemas de superlotação e congestão, enfrentados no Brasil.

Risk Factor Analysis of Extended Opioid Use after Coronary Artery Bypass Grafting: A Clinical Data Warehouse-Based Study / 대한의료정보학회지

OBJECTIVES: A clinical data warehouse (CDW) is part of our hospital information system, and it provides user-friendly ‘data search and extraction’ interfaces for query composition. We carried out a risk factor analysis for the extended use of opioids after coronary artery bypass grafting (CABG), taking advantage of the CDW system. METHODS: From 2015 to 2017, clinical data from 461 patients who had undergone either isolated or concomitant CABG were extracted using the CDW; the extracted data included baseline patient characteristics, various examination results, and opioid prescription information. Supplementary data that could not be extracted with the CDW were collected via manual review of the electronic medical records. RESULTS: Data from a total of 447 patients were analyzed finally. The mean patient age was 66.8 ± 10.9 years, 332 patients (74%) were male, and 235 patients (53%) had diabetes. Among the 447 patients, 90 patients (20.1%) took some type of opioid at the 15th postoperative day. An oral rapid-acting agent was the most frequently used opioid (83%). In the risk factor analysis for extended opioid use, duration of operation was the only significant risk factor (odds ratio = 1.004; 95% confidence interval, 1.001–1.007; p = 0.008). CONCLUSIONS: Longer operation time was associated with the risk of extended opioid use after CABG. CDW was a helpful tool for extracting mass clinical data rapidly, but to maximize its utility, the data should be checked carefully as they are entered in the system so that post-processing can be minimized. Further refinement of the clinical data input and output interface is warranted.

Automatic synonyms extraction of TCM terms through pattern recognition / 国际中医中药杂志

The national basic science and technology projects (No.2012FY130100) help us design and use the method of automatic extraction of TCM term synonyms based on pattern recognition. This method included 6 steps: preparing the dictionaries, compiling extraction programs, extracting synonyms based on the pattern rules, auditing the results, merging synonyms and evaluating the effectiveness. Statistical data showed that the accuracy of synonym extraction by this method was about 94％, and the recall rate was about 94.5％. Therefore, the automatic synonym extraction of TCM terms based on pattern recognition could improve the efficiency of synonym extraction.

Implantação e uso de sistema de rastreabilidade automatizado em central de materiais e esterilização / Implementation and use of automated traceability system in the central sterile supply department / Implantación y uso de sistema de rastreabilidad automatizado en central de materiales y esterilización

Objetivo: Descrever a implantação do sistema de rastreabilidade automatizada no Centro de Material e Esterilização (CME). Método: Relato de experiência desenvolvido entre 2011 e 2014. Foi escolhido o sistema de rastreabilidade mais adequado ao perfil da instituição e adquiridas as licenças básicas. Necessária adaptação da infraestrutura e treinamento. Resultados: Optou-se por rastrear a caixa por meio de código de barras. Iniciou-se pelo banco de dados. Realizou-se cadastro das caixas e impressão da etiqueta. Após um mês, 3 caixas estavam cadastradas e 81 unidades com rastreabilidade criadas; no terceiro mês, 698 unidades; e após 9 meses, 7.669 unidades foram criadas. São esquecidas 5,0% das etapas; 4,2% são corrigidas; e 0,8% perdem a rastreabilidade por erro humano. A gestão é realizada por meio de relatórios e discussão dos resultados. A implantação total durou nove meses. Conclusão: Mesmo com a incipiência do método, este estudo demonstra que o sistema de rastreabilidade automatizado trouxe benefícios ao CME do hospital.

Objective: To describe the implementation of the automated traceability system in Central Sterile Supply Department (CSSD). Method: Experiment report developed between 2011 and 2014. The traceability system best suited to the profile of the institution was chosen, and its basic license was purchased. The proper infrastructure and training were also adapted. Results: We decided to trace cases with barcodes. We began with the database; the cases were registered, and the labels printed. After one month, three cases were registered and 81 traceable units were created; in the third month, 698 units were created; after nine months, 7,669 units were created. Of the total number of stages, 5.0% are omitted; 4.2% are corrected; and 0.8% loose traceability owing to human error. Management is performed through reports and the discussion of results. Total implementation lasted nine months. Conclusion: Even with the incipience of the method, this study demonstrates that the automated traceability system benefits the hospital's CSSD.

Objetivo: Describir la implantación del sistema de rastreabilidad automatizada en el Centro de Material y Esterilización (CME). Método: Relato de experiencia desarrollada entre 2011 y 2014. Fue escogido el sistema de rastreabilidad más adecuado al perfil de la institución y adquiridas las licencias básicas. Necesaria adaptación de la infraestructura y capacitación. Resultados: Se optó por rastrear la caja por medio de código de barras. Se empezó por el banco de datos. Se realizó el registro de las cajas e impresión de la etiqueta. Tras un mes, 3 cajas estaban registradas y 81 unidades con rastreabilidad creadas; en el tercer mes, 698 unidades; y tras 9 meses, 7.669 unidades fueron creadas. Son olvidadas un 5,0% de las etapas; un 4,2% son corregidas; y un 0,8% pierden la rastreabilidad por error humano. La gestión es realizada por medio de informes y discusión de los resultados. La implantación total duro nueve meses. Conclusión: Incluso con la insipiencia del método, este estudio demuestra que el sistema de rastreabilidad automatizado trajo beneficios al CME del hospital.

Textual Research on Traditional Effect Verification of Belamcanda chinensis and Its Pharmacological Experimental Verification / 世界科学技术-中医药现代化

Through reviewing ancient and modern literatures,the effect evolution and disease treatment changes of Belamcanda chinensis were understood.The pharmacological experiments were used to verify its main effects.The combination of featured advantages of traditional Chinese medicine (TCM) and modern science and technology contributed to the promotion of TCM modernization.It had important significance for the development of effective components,selection of disease types in the treatment for research and development of new TCM drugs.The indication of Belamcanda chinensis was verified from textual research.The treatment of disease types by Belamcanda chinensis was verified from medical books.The treatment of disease types by Belamcanda chinensis compound was analyzed based on the Pujifang database management system.Main indications of Belamcanda chinensis were summarized.Modern pharmacological studies on anti-inflammatory mechanism of main components of Belamcanda chinensis were combined to screen animal models and investigation indexes for the preliminary verification of the efficacy of Belamcanda chinensis.The comprehensive application of classical herbal medicine books and prescription database analysis results showed that removing phlegm and relieving sore throat were the efficacy of Belamcanda chinensis,which was an important medicine in the treatment of pharyngitis and sore throat.In the modern research,serum of experimental group,IL-4 in throat tissues,as well as IgE and LTC4 level in serum and lung tissues were significantly reduced compared to the model group (P＜0.05).It was concluded that the treatment effect of Belamcanda chinensis extract to chronic pharyngitis may be through the decreasing of IgE level in serum and lung tissues,inhibiting IL-4 expression in serum and throat tissues,and the LTC4 expression in serum.

Cost-Effective Mobile-Based Healthcare System for Managing Total Joint Arthroplasty Follow-Up / 대한의료정보학회지

OBJECTIVES: Long-term follow-up care after total joint arthroplasty is essential to evaluate hip and knee arthroplasty outcomes, to provide information to physicians and improve arthroplasty performance, and to improve patients' health condition. In this paper, we aim to improve the communication between arthroplasty patients and physicians and to reduce the cost of follow-up controls based on mobile application technologies and cloud computing. METHODS: We propose a mobile-based healthcare system that provides cost-effective follow-up controls for primary arthroplasty patients through questions about symptoms in the replaced joint, questionnaires (WOMAC and SF-36v2) and the radiological examination of knee or hip joint. We also perform a cost analysis for a set of 423 patients that were treated in the University Clinic for Orthopedics in Essen-Werden. RESULTS: The estimation of healthcare costs shows significant cost savings (a reduction of 63.67% for readmission rate 5%) in both the University Clinic for Orthopedics in Essen-Werden and the state of North Rhine-Westphalia when the mobile-based healthcare system is applied. CONCLUSIONS: We propose a mHealth system to reduce the cost of follow-up assessments of arthroplasty patients through evaluation of diagnosis, self-monitoring, and regular review of their health status.

Prevalência de hipertensos e diabéticos cadastrados e acompanhados pelas unidades de saúde do município de Cascavel - Paraná / Prevalence of hypertensive and diabetic patients registered and monitored by health units in the city of Cascavel, Paraná

Estudos epidemiológicos constatam que, no Brasil, a hipertensão arterial sistêmica (HAS) e o Diabetes Mellitus (DM) estão sendo reconhecidos como um importante problema de saúde pública, ocupando um percentual de 30 a 40% das causas de morbidade. Estudos também têm demonstrado uma associação entre essas doenças e patologias bucais, sugerindo que as infecções bucais podem aumentar o risco para doenças sistêmicas, mas também o portador de doenças sistêmicas pode apresentar uma susceptibilidade maior para o desenvolvimento de patologias bucais, especialmente a doença periodontal. Nesse contexto, o objetivo deste estudo foi verificar a prevalência de HAS e DM e a associação de ambas, de acordo com o gênero e a idade de indivíduos do município de Cascavel, por meio do Sistema HiperDia (Sistema de Cadastramento e Acompanhamento de Hipertensos e Diabéticos) do Ministério da Saúde. Os resultados obtidos permitiram identificar que no município de Cascavel existem 26450 pacientes cadastrados no Sistema HiperDia, sendo 3,29% diabéticos, 76,51% hipertensos e 20,19% diabéticos com hipertensão. O número de indivíduos do gênero feminino cadastrados é maior que o do gênero masculino e a prevalência das doenças aumenta com a idade. Conclui- se que o número de hipertensos e diabéticos cadastrados é muito menor do que os valores estimados em cidades brasileiras, sendo necessária uma pesquisa mais abrangente para demonstrar a real prevalência dessas doenças em Cascavel-PR.

Epidemiological studies find that hypertension and diabetes mellitus (DM) are being recognized as an important public health problem in Brazil, occupying a percentage of 30 to 40% of the causes of morbidity. Studies have also shown an association between these diseases and oral pathologies, suggesting that oral infections can increase the risk of systemic diseases, but also that systemic diseases may increase susceptibility to the development of oral diseases, especially periodontal disease. The objective of this study was to assess the prevalence of hypertension and DM, and the combination of both, according to the gender and age of individuals in Cascavel, PR, through the System of Enrollment and Follow-up of Hypertensive and Diabetic Patients (HiperDia) of the Ministry of Health. In Cascavel there were 26,450 patients enrolled in HiperDia, 3.29% being diabetics, 76,51% hypertensive, and 20,19% diabetics with hypertension. A higher number of females are enrolled than males, and the prevalence of these diseases increases with age. The number of hypertensive and diabetic patients enrolled is much lower than the estimated prevalence in Brazilian cities, requiring a larger study to demonstrate the actual prevalence of these diseases in Cascavel, PR.

Ossos ID: uma proposta de banco de dados didático de peças anatômicas para área da saúde / Bones ID: a proposal of didactic database of anatomic parts to health area / Huesos ID: una propuesta de base de datos educativos de estructuras anatómicas para la área de salud

Objetivo: Desenvolvimento e padronização de uma base de dados didática para armazenamento de informações relacionadas às coleções de peças osteológicas humanas acondicionadas no ossário do Departamento de Morfologia da Universidade Federal do Ceará. Método: A presente pesquisa trata-se de um estudo descritivo-exploratório executado em três etapas distintas: na primeira, foi desenvolvida a base de dados OssosID; na segunda etapa foi realizado a aplicação da base de dados OssosID e a terceira etapa consistiu na disponibilização da base de dados OssosID em nuvem, a partir do uso de software gratuito disponível online. Resultados e Conclusão: Após o desenvolvimento, aplicação e disponibilização da base de dados OssosID,foi possível observar que esta plataforma tornou-se viável para o seu uso contínuo e de rotina nas atividades do Departamento de Morfologia da Universidade Federal do Ceará, podendo servir como modelo para outras instituições de ensino e pesquisa devido a sua facilidade de operação e uniformidade.

Objective: Development and standardization of a didactic database to storage information related to human osteological collections of stored pieces in the ossuary of the Department of Morphology (DM) of the Federal University of Ceará (UFC). Method: The present research it is about a study descriptive and exploratory executed in three distinct stages: at first, was developed the based data: OssosID; at the second stage was performed the implementation of the OssosID and the third step consisted in providing the database OssosID in cloud by using a free software available online. Results and Conclusion: After the development, application and availability of the basedata: OssosID, we could observe that this platform has become viable for its continued and routine use in the activities of the Department of Morphology, Federal University of Ceará, and it can be used as a model for other institutions of education and research, by its easy operation and uniformity.

Objetivo: Desarrollo y normalización de una base de datos de enseñanza para almacenar información relacionada con las colecciones osteológicas de datos piezas que se conservan en el osario del Departamento de Morfología (DM) de la Universidad Federal de Ceará (UFC). Método: La presente investigación es un estudio descriptivo y exploratorio, ejecutado en tres etapas distintas: en primer lugar, fue desarrollado el base de datos: OssosID; la segunda etapa se llevó a cabo la aplicación de la base de datos OssosID y el tercer paso consistió en el suministro de el base OssosID nube de la utilización de software libre disponible en línea. Resultados y Conclusión: Después del desarrollo, la aplicación y la disponibilidad de los datos OssosID base, se observó que esta plataforma sea posible para su uso continuado y rutinaria en las actividades del Departamento de Morfología de la Universidad Federal de Ceará, pueden servir como un modelo para otras instituciones educativas y de investigación, debido a su facilidad de operación y la uniformidad.

Improving Indicators in a Brazilian Hospital Through Quality-Improvement Programs Based on STS Database Reports

ABSTRACT OBJECTIVE: To report the initial changes after quality-improvement programs based on STS-database in a Brazilian hospital. METHODS: Since 2011 a Brazilian hospital has joined STS-Database and in 2012 multifaceted actions based on STS reports were implemented aiming reductions in the time of mechanical ventilation and in the intensive care stay and also improvements in evidence-based perioperative therapies among patients who underwent coronary artery bypass graft surgeries. RESULTS: All the 947 patients submitted to coronary artery bypass graft surgeries from July 2011 to June 2014 were analyzed and there was an improvement in all the three target endpoints after the implementation of the quality-improvement program but the reduction in time on mechanical ventilation was not statistically significant after adjusting for prognostic characteristics. CONCLUSION: The initial experience with STS registry in a Brazilian hospital was associated with improvement in most of targeted quality-indicators.

A comprehensive protocol to evaluate the use of blood and its components in Latin America and the Caribbean / Un protocolo integral para evaluar el uso de la sangre y sus componentes en América Latina y el Caribe

Blood transfusion safety is a critical part of appropriate health care. Considering the limited information available on the use of blood and its components in Latin America and the Caribbean, the Grupo Cooperativo iberoamericano de Medicina Transfusional (Ibero-American Cooperative Group for Transfusion Medicine; GCIAMT), through its Research and International Affairs committees, carried out a project to develop a protocol that would facilitate the evaluation of blood usage at the country, jurisdiction, and institutional levels in varied country contexts. Experts in blood safety from the Pan American Health Organization (Washington, DC, United States), the University of São Paulo (São Paulo, Brazil), the Hemocentro of São Paulo (São Paulo, Brazil), and GCIAMT designed a 2-step comprehensive blood-use evaluation protocol: step 1 collects data from blood requests, and step 2, from medical charts. At a minimum, 1 000 analyzed requests are necessary; as such, study periods vary depending on the number of transfusion requests issued. An Internet-based application, the Modular Research System-Study Management System (MRS-SMS), houses the data and produces reports on how hospitals request blood, how blood is issued, who requires blood and blood components, and as an added benefit, how many blood units are wasted and what the real demand for blood is.

La seguridad de las transfusiones de sangre constituye una parte fundamental de una apropiada atención de salud. Teniendo en cuenta la limitada información disponible sobre el uso de la sangre y sus componentes en América Latina y el Caribe, el Grupo Cooperativo Iberoamericano de Medicina Transfusional (GCIAMT), mediante sus comités de Investigación y de Asuntos Internacionales, llevó a cabo un proyecto de elaboración de un protocolo que facilitara la evaluación del uso de la sangre a nivel de país, jurisdiccional e institucional, en diversos contextos de país. Expertos en seguridad de la sangre de la Organización Panamericana de la Salud (Washington, DC, Estados Unidos), la Universidad de São Paulo (São Paulo, Brasil), el Hemocentro de São Paulo (São Paulo, Brasil) y el GCIAMT diseñaron un protocolo integral de evaluación del uso de la sangre en 2 etapas: en la primera se recopilan datos de las solicitudes de sangre, y en la segunda, de las historias clínicas. Como mínimo, es preciso analizar 1 000 solicitudes; por ello, los períodos de estudio varían en dependencia del número de solicitudes de transfusión expedidas. Una aplicación basada en internet, el Modular Research System, Study Management System, alberga los datos y elabora informes sobre cómo solicitan sangre los hospitales, cómo se expide la sangre, quién requiere sangre y componentes sanguíneos y, como beneficio añadido, cuántas unidades de sangre se desperdician y cuál es la demanda real de sangre.

Investigation and Analysis on Potential Function of Euodia rutaecarpa / 世界科学技术-中医药现代化

Through the investigation on functions of E.rutaecarpain ancient herbal literatures,ancient prescriptions and the Chinese Pharmacopoeia(2010 edition),it showed that the basic function of E.rutaecarpa recorded in herbal literatures through dynasties was similar to that of the Chinese Pharmacopoeia.However,the disappearance of Euodia rutaecarpa's functions in the Chinese Pharmacopoeia were dampness-eliminating,blood-activating,spleen-invigorating,phlegm-eliminating,wind-dispelling,and guiding fire to its source,which had been recorded in ancient herb literatures.ThePu-Ji-Fang database management system contained prescriptions with Euodia rutaecarpa in the treatment of asthenia,Bi syndrome,stroke,scabies,edema,phlegm,leukorrhagia,epigastric pain,menoxenia,lochiostasis,fractures,sore,aphtha,and etc,which were absent from the Chinese Pharmacopoeia.In conclusion,we preliminarily confirmed that Euodia rutaecarpahad potential functions in activating blood to resolve stasis,dispelling wind and eliminating dampness,nourishing deficiency and invigorating the spleen,resolving toxins,relieving cough and eliminating phlegm,soothing liver to stop wind,as well as stopping bleeding.

Exploitation and Utilization on Potential Function ofPoria cocos / 世界科学技术-中医药现代化

This study took herbal medicinePoria cocosas an example to establish a method to explore the potential function of herbal medicine. And then, the new function was identified through the systematic study. It was able to improve the application range of herbal medicine and the clinical therapeutic effects. The established database management system ofPu-Ji-Fanghad been used for the searching ofPoria cocosin the treatment of different diseases in order to receive the compound prescription containedPoria cocos in different diseases. Then, indications recorded in herbalism literatures through dynasties and thePharmacopoeia of People’s Republic of China(Chinese Pharmacopoeia) were compared. Through statistical analysis and logical judgment, as well as the combination of modern pharmacological research results and clinical therapeutic evaluations, the overall understanding on conventional and potential functions ofPoria cocos were received. The results showed that the functions ofPoria cocos summarized through dynasties contained alleviating thirst, eliminating phlegm, enhancing memory, astringent, relieving cough and vomiting, invigorating blood circulation, promoting appetite and securing fetus, as well as treatment of deficiency, vomiting, stroke, diabetes, cough, cold damage syndrome, convulsion and other syndrome, were not recorded in theChinese Pharmacopoeia. It was concluded that tonifying kidney, relieving cough and phlegm, relieving vomiting, alleviating thirst, expelling wind, relieving convulsion and securing fetus were the potential function ofPoria cocos, which should arouse the attention from the academic community.

Exploration and Utilization of the Potential Functions of Gentian / 世界科学技术-中医药现代化

Itis confirmed that the core part of traditional functions of gentian is consistent with the record in Pharmacopoeia by comparison the gentian function recorded in ancient literatures, prescription andPharmacopoeia. We found some functions and disease treatments by gentian were not recorded by Pharmacopoeia. These functions summarized by ancient literatures included heat-clearing and detoxifying, eliminate rickets, tranquilizing, cooling blood and hemostasis and chlordimeform. And inPuji Prescriptions database those disease treatments by gentian included sore, rickets, feeling uneasy, seizures and bleeding. By analyzing the literature and combination with the results of modern pharmacology and clinical medicine research, it is believed that the potential functions of gentian are heat-clearing and detoxifying, rickets eliminating, tranquilizing, blood cooling and hemostasis and chlordimeform.

Investigation and Analysis on Potential Functions ofGentiana Macrophylla / 世界科学技术-中医药现代化

Through the investigation ofGentiana macrophylla in herbalism literatures, ancient prescriptions and theChinese Pharmacopoeia 2010 edition, we found that functions from ancient herbalism and prescriptions were in conformity with those from theChinese Pharmacopoeia. However, other functions recorded in ancient literatures such as dissipating wind, calming the liver to stop wind, clearing heat-fire, stopping bleeding, relieving cough were not included in theChinese Pharmacopoeia. With modern studies on pharmacodynamics and clinical applications, these functions were primarily conformed as the lost potential functions ofG. macrophylla.

Exploration and Utilization on Potential Function ofRehmannia Glutinosa / 世界科学技术-中医药现代化

This study was aimed to investigate the functions and indications ofRehmannia glutinosa from old herbalism documents. The database management system ofPu-Ji-Fang was used to summarize the whole function, which was compared with theChinese Pharmacopoeia 2010 edition. The results showed that besides the same function,R. glutinosa was also widely used in the treatment of various heat syndromes, deficiency, sore ulcer, traumatism, irregular menstruation, arthralgia, blood stasis, apoplexia, cough, restlessness, and etc. With modern studies on pharmacodynamics and clinical applications, potential functions ofR. glutinosa were primarily conformed as clearing heat-fire (clearing heat-toxin), tonifying, promoting blood circulation to remove blood stasis, soothing nerves, calming liver to extinguish wind, and removing wind-damp syndromes.

Aplicação de Análise de Cluster em dados integrados de um estudo prospectivo: projeto epidoso como cenário / Application of Cluster Analysis in integrated data of a prospective study: project epidoso as a scenario / Aplicación del Análisis del Grupo en datos integrados de un estudio prospectivo: proyecto epidos como escenario

Objetivo: Este estudo apresenta o reforço nas comunicações entre grupos de pesquisadores com o benefício de portais web, assim como buscou um olhar diferente na análise dos dados de um estudo de coorte possibilitando identificar grupos de indivíduos com características socioeconômicas e agravos ou vulnerabilidades semelhantes para um melhor desenho de promoção de saúde. Método: Estudo exploratório, de abordagem qualitativa e quantitativa, analítico, do tipo estudo de caso. Resultados: Os dados foram normalizados e transferidos para uma base de dados relacional. O portal web permitiu acesso mais seguro aos dados e com alta disponibilidade. Das 207 variáveis iniciais, apenas 56 foram selecionadas da análise de cluster, na qual foram identificados três grupos de indivíduos. Conclusões: Pesquisas longitudinais com vários grupos de pesquisa necessitam usar bases relacionais com alta disponibilidade e segurança. O acesso aos dados pode ser feito por meio da Internet com acesso controlado. A identificação de grupos permite uma promoção e comunicação em saúde com melhores resultados.

Objective: This study presents the strengthening of communications among groups of researchers with the benefit of web portals, and sought a different look in the analysis of data from a cohort study enabling to identify groups of individuals with similar socioeconomic, health problems or vulnerabilities to a better planning of health promotion. Method: This was an exploratory study of qualitative and quantitative approach, analytic, case study. Results: The data were normalized and transferred to a relational database. The web portal allowed more secure access to data, thus researchers now have safe access and high availability of data. In cluster analysis, it was identified three groups of subjects. Conclusions: Longitudinal research with some or several research groups need to use relational databases with high availability and security of data. Access to data can be done through the Internet with controlled access. Cluster analysis, especially the method TwoStep, identifies groups of individuals with socioeconomic and health problems or similar vulnerabilities without having to report the number of groups. This allows creation of groups in health promotion and communication with better results.

Objetivo: Este estudio presenta el fortalecimiento de las comunicaciones entre grupos de investigadores con el beneficio de portales web, y buscó una mirada diferente en el análisis de los dados de un estudio de cohortes con la posibilidad de identificar grupos de individuos con socioeconómica y los mismos peligros o vulnerabilidades para un mejor diseño de promoción de la salud. Método: Un estudio exploratorio de abordaje cualitativo y cuantitativo, el estudio de caso analítico. Resultados: Los datos se normalizaron y se transfiere a una base de datos relacional. El portal de Internet ha permitido un acceso más seguro a los datos, ahora tenemos acceso a una alta disponibilidad. De las 207 variables iniciales, sólo 56 participaron en el análisis de conglomerados, que se identificaron tres grupos de personas. Conclusiones: La investigación longitudinal con diversos grupos de investigación que utilizar bases de datos relacionales con alta disponibilidad y seguridad. El acceso a datos puede hacerse a través de Internet con acceso controlado. El análisis de clusters, en particular el método TwoStep permite identificar grupos de individuos con riesgos socioeconómicos y similares o vulnerabilidades, sin tener que informar el número de grupos. Esto permite la creación de grupos de promoción de la salud y la comunicación, con mejores resultados.